WHI strives to improve health through research on risk factors, prevention, and early detection of serious health conditions, so postmenopausal women thrive.

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Impacting lives through groundbreaking research

Impacting lives through groundbreaking research
161,000 +study participants
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5.3 millionspecimen vials collected and documented
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12,600fewer cases of breast cancer each year as a result of WHI research
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The Women’s Health Initiative is a landmark study that has had a huge impact on medical practice and public health.

— Gary H. Gibbons, M.D., NHLBI Director
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2,392papers published to date using WHI datapapers published using WHI data
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WHI News

Remembering Gloria Sarto

Remembering Gloria Sarto

We are saddened to inform you of the passing of one of the WHI’s esteemed Investigators Dr. Gloria Sarto.
WHI Highlighted at 75th Anniversary of NHLBI

WHI Highlighted at 75th Anniversary of NHLBI

WHI Profile in celebration of NHLBI’s 75th anniversary, featuring a WHI Participant
Radon Exposure and Stroke Risk in the Women's Health Initiative

Radon Exposure and Stroke Risk in the Women's Health Initiative

A paper studying the association between radon and stroke in woman has been published in the online issue of Neurology, the medical journal of the American Academy of Neurology
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Recent Publications

Relationships of depression and antidepressant use with epigenetic age acceleration and all-cause mortality among postmenopausal women

May Baydoun et al., 2924/5 PubMed #38809417

Ductal carcinoma in situ and cause-specific mortality among younger and older postmenopausal women: the Women's Health Initiative

Kathy Pan et al., 2024/5 PubMed #38730133

The Women’s Health Initiative randomized trials and clinical practice: A review

JoAnn Manson et al., 2024/5 PubMed #38691368

Breast cancer incidence and mortality by metabolic syndrome and obesity: The Women's Health Initiative

Rowan Chlebowski et al., 2024/5 PubMed #38736319

African ancestry-derived APOL1 risk genotypes show proximal epigenetic associations

Charles Breeze et al., 2024/5 PubMed #38714935

Associations of tubal ligation and hysterectomy with serum androgen and estrogen metabolites among postmenopausal women in the Women’s Health Initiative Observational Study

Ashley M. Geczik et al., 2024/5 PubMed #38772931

Identifying the relation between food groups and biological ageing; a data-driven approach

Ynte Biemans et al., 2024/5 PubMed #38745494

Differences in metabolomic profiles between Black and White Women in the U.S.: Analyses from two prospective cohorts

Emma McGee et al., 2024/5 PubMed #38703248

Plasma oxysterols are associated with serum lipids and dementia risk in older women

Michelle Dunk et al., 2024/4 PubMed #38574442

Epidemiologic factors in relation to colorectal cancer risk and survival by genotoxic colibactin mutational signature

Claire Thomas et al., 2024/4 PubMed #38252034

Risk of adverse cardiovascular outcomes in postmenopausal women with inflammatory bowel disease

Ruby Greywoode et al., 2024/4 PubMed #38684633

Randomized trials of estrogen-alone and breast cancer incidence: a meta-analysis

Rowan Chlebowski et al., 2024/4 PubMed #38653905

20-year depressive symptoms, dementia, and structural neuropathology in older women

Andrew J. Petkus et al., 2024/4 PubMed #38591250

Correlates of physical activity and sedentary behavior among cancer survivors and Cancer-Free Women: The Women’s Health Accelerometry Collaboration

Samantha Schilsky et al., 2024/4 PubMed #38573893

Loneliness, social isolation, and cardiovascular disease among nonveteran and veteran women

Natalie Golaszewski et al., 2024/4 PubMed #38659158

Infertility and risk of postmenopausal breast cancer in the Women’s Health Initiative

Leslie Farland et al., 2024/3 PubMed #38459395

Longitudinal Associations Between Optimism and Objective Measures of Physical Functioning in Women

Hayami K. Koga et al., 2024/3 PubMed #38506825

Physical function trajectory after wrist or lower arm fracture in postmenopausal women: Results from the Women’s Health Initiative Study

Carolyn Crandall et al., 2024/3 PubMed #38459975

Depressive symptoms and antidepressant use in relation to white blood cell count among postmenopausal women from the Women’s Health Initiative

Hind Beydoun et al., 2024/3 PubMed #38514652

Relationship of psychotropic medication use with physical function among postmenopausal women

Hind Beydoun et al., 2024/3 PubMed #38517642

Want to view more works by WHI investigators? Visit our publications page