WHI strives to improve health through research on risk factors, prevention, and early detection of serious health conditions, so postmenopausal women thrive.

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Impacting lives through groundbreaking research

Impacting lives through groundbreaking research
161,000 +study participants
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5.3 millionspecimen vials collected and documented
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12,600fewer cases of breast cancer each year as a result of WHI research
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The Women’s Health Initiative is a landmark study that has had a huge impact on medical practice and public health.

— Gary H. Gibbons, M.D., NHLBI Director
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2,373papers published to date using WHI datapapers published using WHI data
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WHI News

WHI Highlighted at 75th Anniversary of NHLBI

WHI Highlighted at 75th Anniversary of NHLBI

WHI Profile in celebration of NHLBI’s 75th anniversary, featuring a WHI Participant
Radon Exposure and Stroke Risk in the Women's Health Initiative

Radon Exposure and Stroke Risk in the Women's Health Initiative

A paper studying the association between radon and stroke in woman has been published in the online issue of Neurology, the medical journal of the American Academy of Neurology
2023 WHI Investigators Meeting

2023 WHI Investigators Meeting

Registration is now open for the 2023 WHI Investigators Meeting! Please see the attached link for registration information. More details to follow.
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Recent Publications

Infertility and risk of postmenopausal breast cancer in the Women’s Health Initiative

Leslie Farland et al., 2024/3 PubMed #38459395

Depressive symptoms and antidepressant use in relation to white blood cell count among postmenopausal women from the Women’s Health Initiative

Hind Beydoun et al., 2024/3 PubMed #38514652

Long-Term Effect of Randomization to Calcium and Vitamin D Supplementation on Health in Older Women : Postintervention Follow-up of a Randomized Clinical Trial

Cynthia Thomson et al., 2024/3 PubMed #38467003

Accelerometer-measured physical activity, sedentary time and heart failure risk in women ages 63-99 years

Michael LaMonte et al., 2024/2 PubMed #38381446

Fatty acid intake and polyunsaturated fatty acid biomarkers and risk of total knee or hip arthroplasty among older women in the Women’s Health Initiative

Tonya Orchard et al., 2024/2 PubMed #38412867

Biomarker-assessed total energy intake and its association with all-cause mortality in postmenopausal women

Ross Prentice et al., 2024/2 PubMed #38428741

Improving polygenic risk prediction in admixed populations by explicitly modeling ancestral-specific effects via GAUDI

Yun Li et al., 2024/2 PubMed #38310129

Long-term dietary influence on physical functioning: the Women’s Health Initiative randomized Dietary Modification trial

Rowan Chlebowski et al., 2024/2 PubMed #38395355

Associations of accelerometer-measured physical activity and sedentary behavior with incident clinical osteoporotic fractures among older women: the OPACH study

Steve Nguyen et al., 2024/2 PubMed #38410939

Practical considerations for sandwich variance estimation in two-stage regression settings

Lillian Boe et al., 2024/2 PubMed #38012109

Traditional Mexican dietary pattern and cancer risk among women of Mexican descent

Nicole Lorona et al., 2024/2 PubMed #38305935

Photosensitizing antihypertensive medication and risk of skin cancer among postmenopausal women

Alexander Hou et al., 2024/2 PubMed #38345266

Engagement With Remote Delivery Channels in a Physical Activity Intervention for Senior Women in the US

Andrea Mendoza-Vasconez et al., 2024/2 PubMed #38344760

Using simultaneous regression calibration to study the effect of multiple error-prone exposures on disease risk utilizing biomarkers developed from a controlled feeding study

Yiwen Zhang et al., 2024/2 PubMed #38313601

Radon Exposure, clonal Hematopoiesis, and stroke susceptibility in the Women's Health Initiative

Kurt Anthony et al., 2024/1 PubMed #38170948

Alcohol consumption and the diversity of the oral microbiome in postmenopausal women

Amy Millen et al., 2024/1 PubMed #37913907

Dietary patterns and epigenetic aging in the Women’s Health Initiative

Lindsay Reynolds et al., 2024/1 PubMed #38215906

Dietary carbohydrate intake is associated with the subgingival plaque oral microbiome abundance and diversity in a cohort of postmenopausal women

Amy Millen et al., 2024/1 PubMed #35173205

Comparison of PM2.5 air pollution exposures and health effects associations using 11 different modeling approaches in the Women's Health Initiative Memory Study (WHIMS)

Melinda Power et al., 2024/1 PubMed #38226465

Association of social support with mild cognitive impairment and dementia among older women: Women’s Health Initiative Memory Study

Alexander Posis et al., 2023/undefined PubMed #36565123

Individual and neighborhood-level socioeconomic status and somatic mutations associated with increased risk of cardiovascular disease and mortality: A cross-sectional analysis in the Women's Health Initiative

Shelly-Ann Love et al., 2023/12 PubMed #38061917

Racial disparities in stroke incidence in the Women’s Health Initiative: Exploring biological, behavioral, psychosocial, and social risk factors

Larissa Calancie et al., 2023/12 PubMed #38313870

Measuring diet by metabolomics: a 14-d controlled feeding study of weighed food intake

Mary Playdon et al., 2023/12 PubMed #38212160

Menopausal hormone therapy use and risk of ovarian cancer by race: the Ovarian Cancer in Women of African Ancestry Consortium

Jessica Petrick et al., 2023/12 PubMed #37865688

Associations of dietary patterns with kidney cancer risk, kidney cancer-specific mortality and all-cause mortality among postmenopausal women

Fred Tabung et al., 2023/12 PubMed #37898720

Discontinuation of hormone therapy and bone mineral density: Does physical activity modify that relationship?

Michael LaMonte et al., 2023/12 PubMed #38019034

Allostatic load and risk of invasive breast cancer among postmenopausal women in the U.S

Fengge Wang et al., 2023/12 PubMed #38097139

Hysterectomy, oophorectomy and risk of Non-Hodgkin’s lymphoma

Juhua Luo et al., 2023/12 PubMed #38112671

Stressful life events, social support, and epigenetic aging in the Women’s Health Initiative

Harlyn Skinner et al., 2023/12 PubMed #38149693

Caregiving and all-cause mortality in postmenopausal women: findings from the Women's Health Initiative

Prachi Chavan et al., 2023/11 PubMed #37936486

Want to view more works by WHI investigators? Visit our publications page