WHI strives to improve health through research on risk factors, prevention, and early detection of serious health conditions, so postmenopausal women thrive.

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Impacting lives through groundbreaking research

Impacting lives through groundbreaking research
161,000 +study participants
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5.3 millionspecimen vials collected and documented
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12,600fewer cases of breast cancer each year as a result of WHI research
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The Women’s Health Initiative is a landmark study that has had a huge impact on medical practice and public health.

— Gary H. Gibbons, M.D., NHLBI Director
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2,389papers published to date using WHI datapapers published using WHI data
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WHI News

WHI Highlighted at 75th Anniversary of NHLBI

WHI Highlighted at 75th Anniversary of NHLBI

WHI Profile in celebration of NHLBI’s 75th anniversary, featuring a WHI Participant
Radon Exposure and Stroke Risk in the Women's Health Initiative

Radon Exposure and Stroke Risk in the Women's Health Initiative

A paper studying the association between radon and stroke in woman has been published in the online issue of Neurology, the medical journal of the American Academy of Neurology
2023 WHI Investigators Meeting

2023 WHI Investigators Meeting

Registration is now open for the 2023 WHI Investigators Meeting! Please see the attached link for registration information. More details to follow.
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Recent Publications

Differences in metabolomic profiles between Black and White Women in the U.S.: Analyses from two prospective cohorts

Emma McGee et al., 2024/5 PubMed #38703248

Ductal carcinoma in situ and cause-specific mortality among younger and older postmenopausal women: the Women's Health Initiative

Kathy Pan et al., 2024/5 PubMed #38730133

Associations of tubal ligation and hysterectomy with serum androgen and estrogen metabolites among postmenopausal women in the Women’s Health Initiative Observational Study

Ashley M. Geczik et al., 2024/5 PubMed #38772931

The Women’s Health Initiative randomized trials and clinical practice: A review

JoAnn Manson et al., 2024/5 PubMed #38691368

African ancestry-derived APOL1 risk genotypes show proximal epigenetic associations

Charles Breeze et al., 2024/5 PubMed #38714935

Identifying the relation between food groups and biological ageing; a data-driven approach

Ynte Biemans et al., 2024/5 PubMed #38745494

Breast cancer incidence and mortality by metabolic syndrome and obesity: The Women's Health Initiative

Rowan Chlebowski et al., 2024/5 PubMed #38736319

Risk of adverse cardiovascular outcomes in postmenopausal women with inflammatory bowel disease

Ruby Greywoode et al., 2024/4 PubMed #38684633

20-year depressive symptoms, dementia, and structural neuropathology in older women

Andrew J. Petkus et al., 2024/4 PubMed #38591250

Randomized trials of estrogen-alone and breast cancer incidence: a meta-analysis

Rowan Chlebowski et al., 2024/4 PubMed #38653905

Loneliness, social isolation, and cardiovascular disease among nonveteran and veteran women

Natalie Golaszewski et al., 2024/4 PubMed #38659158

Correlates of physical activity and sedentary behavior among cancer survivors and Cancer-Free Women: The Women’s Health Accelerometry Collaboration

Samantha Schilsky et al., 2024/4 PubMed #38573893

Plasma oxysterols are associated with serum lipids and dementia risk in older women

Michelle Dunk et al., 2024/4 PubMed #38574442

Longitudinal Associations Between Optimism and Objective Measures of Physical Functioning in Women

Hayami K. Koga et al., 2024/3 PubMed #38506825

Long-Term Effect of Randomization to Calcium and Vitamin D Supplementation on Health in Older Women : Postintervention Follow-up of a Randomized Clinical Trial

Cynthia Thomson et al., 2024/3 PubMed #38467003

Infertility and risk of postmenopausal breast cancer in the Women’s Health Initiative

Leslie Farland et al., 2024/3 PubMed #38459395

Physical function trajectory after wrist or lower arm fracture in postmenopausal women: Results from the Women’s Health Initiative Study

Carolyn Crandall et al., 2024/3 PubMed #38459975

Low physical function post-cancer diagnosis is associated with higher mortality risk in postmenopausal women

Paola Gonzalo Encabo et al., 2024/3 PubMed #38449287

Relationship of psychotropic medication use with physical function among postmenopausal women

Hind Beydoun et al., 2024/3 PubMed #38517642

Depressive symptoms and antidepressant use in relation to white blood cell count among postmenopausal women from the Women’s Health Initiative

Hind Beydoun et al., 2024/3 PubMed #38514652

Heart failure risk among African American Women with an ICAM1 Missense variant

Ravi Patel et al., 2024/3 PubMed #38530700

Improving polygenic risk prediction in admixed populations by explicitly modeling ancestral-specific effects via GAUDI

Yun Li et al., 2024/2 PubMed #38310129

Biomarker-assessed total energy intake and its association with all-cause mortality in postmenopausal women

Ross Prentice et al., 2024/2 PubMed #38428741

Dietary intervention favorably influences physical functioning: the Women's Health Initiative randomized Dietary Modification trial

Rowan Chlebowski et al., 2024/2 PubMed #38395355

Radon exposure and incident stroke risk in the Women’s Health Initiative

Sophie Buchheit et al., 2024/2 PubMed #38546022

Associations of accelerometer-measured physical activity and sedentary behavior with incident clinical osteoporotic fractures among older women: the OPACH study

Steve Nguyen et al., 2024/2 PubMed #38410939

Practical considerations for sandwich variance estimation in two-stage regression settings

Lillian Boe et al., 2024/2 PubMed #38012109

Traditional Mexican dietary pattern and cancer risk among women of Mexican descent

Nicole Lorona et al., 2024/2 PubMed #38305935

Photosensitizing antihypertensive medication and risk of skin cancer among postmenopausal women

Alexander Hou et al., 2024/2 PubMed #38345266

Prevalence of frequent premature ventricular contractions and nonsustained ventricular tachycardia in older women screened for atrial fibrillation in the Women's Health Initiative

Sofia Gomez et al., 2024/2 PubMed #38403238

Want to view more works by WHI investigators? Visit our publications page